Serological evaluation of an influenza A virus cold-adapted reassortant live vaccine, CR-37 (H1N1), in Japanese adult volunteers
Identifieur interne : 002498 ( Main/Exploration ); précédent : 002497; suivant : 002499Serological evaluation of an influenza A virus cold-adapted reassortant live vaccine, CR-37 (H1N1), in Japanese adult volunteers
Auteurs : N. Yamane [Japon] ; Y. Nakamura [Japon] ; M. Yuki [Japon] ; T. Odagiri [Japon] ; N. Ishida [Japon]Source :
- Journal of Hygiene [ 0022-1724 ] ; 1984-04.
Descripteurs français
- KwdFr :
- Adulte, Anticorps antiviraux (analyse), Antigènes viraux (immunologie), Facteurs temps, Grippe humaine (), Grippe humaine (immunologie), Humains, Hémagglutinines virales (immunologie), Japon, Pharynx (immunologie), Sialidase (immunologie), Sous-type H1N1 du virus de la grippe A, Tests d'inhibition de l'hémagglutination, Tests de fixation du complément, Tests intradermiques, Vaccination, Vaccins antigrippaux (immunologie), Virus de la grippe A (immunologie).
- MESH :
- analyse : Anticorps antiviraux.
- immunologie : Antigènes viraux, Grippe humaine, Hémagglutinines virales, Pharynx, Sialidase, Vaccins antigrippaux, Virus de la grippe A.
- Adulte, Facteurs temps, Grippe humaine, Humains, Japon, Sous-type H1N1 du virus de la grippe A, Tests d'inhibition de l'hémagglutination, Tests de fixation du complément, Tests intradermiques, Vaccination.
- Wicri :
- geographic : Japon.
English descriptors
- KwdEn :
- Adult, Antibodies, Viral (analysis), Antigens, Viral (immunology), Complement Fixation Tests, Hemagglutination Inhibition Tests, Hemagglutinins, Viral (immunology), Humans, Influenza A Virus, H1N1 Subtype, Influenza A virus (immunology), Influenza Vaccines (immunology), Influenza, Human (immunology), Influenza, Human (prevention & control), Intradermal Tests, Japan, Neuraminidase (immunology), Pharynx (immunology), Time Factors, Vaccination.
- MESH :
- chemical , analysis : Antibodies, Viral.
- chemical , immunology : Antigens, Viral, Hemagglutinins, Viral, Influenza Vaccines, Neuraminidase.
- geographic : Japan.
- immunology : Influenza A virus, Influenza, Human, Pharynx.
- prevention & control : Influenza, Human.
- Adult, Complement Fixation Tests, Hemagglutination Inhibition Tests, Humans, Influenza A Virus, H1N1 Subtype, Intradermal Tests, Time Factors, Vaccination.
Abstract
A cold-adapted influenza A virus, CR-37 (H1N1), derived from genetic reassortment between A/Ann Arbor/6/60 (H2N2) cold-adapted variant virus and A/California/10/78 (H1N1) wild-type virus, was tested in Japanese adult volunteers. The CR-37 live virus preparation induced only low-grade clinical reactionsin volunteers for the first 3–4 days after inoculation. Two vaccinees who did not show any antibody changes became febrile (over 38–0 °C). Skin tests using the vaccine preparation and uninfected allantoic fluid were performed, and indicated that one of these two vaccinees was positive for the CR-37 vaccine preparation. A high proportion of the vaccinees whose sera had a haemagglutination-inhibition (HI) antibody titre against thevaccine strain of ≤ 64 before inoculation, seroconverted in both HI and neuraminidase-inhibition (NA1) antibody titrations, and only a few seroconverted in the titration of antibody against type-specific internal antigens. The serological examinations against heterotypic H1N1 variants indicated that the cold-adapted live influenza virus vaccine could induce a broad spectrum of HI antibody reactivity and immunity of long duration.
Url:
DOI: 10.1017/S0022172400064251
Affiliations:
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Le document en format XML
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Odagiri</name><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Bacteriology, Tohoku University School of Medicine, 2-1 Seiryo-machi, Sendai 980</wicri:regionArea><wicri:noRegion>Sendai 980</wicri:noRegion></affiliation></author><author><name sortKey="Ishida, N" sort="Ishida, N" uniqKey="Ishida N" first="N." last="Ishida">N. Ishida</name><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Bacteriology, Tohoku University School of Medicine, 2-1 Seiryo-machi, Sendai 980</wicri:regionArea><wicri:noRegion>Sendai 980</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of Hygiene</title><title level="j" type="abbrev">J. 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The CR-37 live virus preparation induced only low-grade clinical reactionsin volunteers for the first 3–4 days after inoculation. Two vaccinees who did not show any antibody changes became febrile (over 38–0 °C). Skin tests using the vaccine preparation and uninfected allantoic fluid were performed, and indicated that one of these two vaccinees was positive for the CR-37 vaccine preparation. A high proportion of the vaccinees whose sera had a haemagglutination-inhibition (HI) antibody titre against thevaccine strain of ≤ 64 before inoculation, seroconverted in both HI and neuraminidase-inhibition (NA1) antibody titrations, and only a few seroconverted in the titration of antibody against type-specific internal antigens. The serological examinations against heterotypic H1N1 variants indicated that the cold-adapted live influenza virus vaccine could induce a broad spectrum of HI antibody reactivity and immunity of long duration.</div></front></TEI><affiliations><list><country><li>Japon</li></country></list><tree><country name="Japon"><noRegion><name sortKey="Yamane, N" sort="Yamane, N" uniqKey="Yamane N" first="N." last="Yamane">N. Yamane</name></noRegion><name sortKey="Ishida, N" sort="Ishida, N" uniqKey="Ishida N" first="N." last="Ishida">N. Ishida</name><name sortKey="Nakamura, Y" sort="Nakamura, Y" uniqKey="Nakamura Y" first="Y." last="Nakamura">Y. Nakamura</name><name sortKey="Odagiri, T" sort="Odagiri, T" uniqKey="Odagiri T" first="T." last="Odagiri">T. Odagiri</name><name sortKey="Yamane, N" sort="Yamane, N" uniqKey="Yamane N" first="N." last="Yamane">N. Yamane</name><name sortKey="Yuki, M" sort="Yuki, M" uniqKey="Yuki M" first="M." last="Yuki">M. 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